Figure 1.

Schematic Illustration of mRNA-Based Antibody Treatment

In the first step, effective antibodies have to be raised or selected for the target of interest. The respective amino acid sequence can then be encoded in an mRNA designed to produce high amounts of protein. Upon in vivo administration, typically using specific formulations for delivery and mRNA protection against degradation, transfected cells produce the encoded protein, which is not limited as to antibody format or localization. Depending on its mode of action, the mRNA-encoded protein finally triggers the desired therapeutic effect.