Figure 1.

Illustration of the customized CXL treatment.

Notes: ((A) The customized CXL patterns, the fluence of delivery was set to 20 mW/cm2. Upon commencement of the UV treatment the initial circular pattern (red) of 7 mm diameter was treated for a total of 6 Joules delivered over 5 minutes, then the device “focused” its further continuous treatment of 20 mW/cm2 fluence over the intermediate arc pattern (blue) centered on the thinnest point of the cornea, this part of the treatment was an added 3 min and 20 seconds to finally have the device “focus” on the smallest arc pattern (green) that was also centered on the thinnest part of the cornea, as defined by the anterior segment OCT thickness map shown on (B) and for an additional 4 minutes and 10 seconds. This area was treated during the red pattern period (5 minutes) and the blue pattern period (an additional 3 min and 20 seconds) and as noted above for an additional final 4 minutes and 10 seconds to complete a TOTAL amount of continuous energy delivered of 15 Joules. The relative time exposures and energy delivered for each pattern is noted in map 1A. Map 1B illustrates the definition of the (x, y) Cartesian coordinates on the anterior segment OCT thickness map of the cornea, that would serve as the center of the two smaller arc customized treatment profiles, in respect to the pupil center, the “target” for the tracker of the KXL-II device during customized UV light pattern delivery. (C) The map illustrates the superimposition of the treatment patterns on the thickness map mentioned above.