Table 1.
Litters and treatment groups used in the trial; piglets were infected on study day 3 and treated with BKI 1369 from study day 3–7.
| Group | Infection with C. suis strain | Litter No. | No. of piglets in total | No. of piglets that completed the studyc | Treatment |
|---|---|---|---|---|---|
| Wien-BKI | Wien-I | 1, 2, 3 | 13 | 10 | BKI; 10 mg/kg BW, twice daily |
| Wien-Ctrl | Wien-I | 1, 2, 3 | 12 | 9 | Mocka; twice daily |
| Holl-BKI | Holland-I | 4 | 5 | 5 | BKI; 10 mg/kgb BW, twice daily |
| Holl-Ctrl | Holland-I | 4 | 5 | 5 | Mocka; twice daily§ |
a
Mock: solvent (3% Tween 80 + 7% ethanol + 90% 0.9% NaCl).
b
Piglets infected with Holland-I strain (Holl-BKI & Holl-Ctrl) were additionally treated with 20 mg/kg BW toltrazuril.
c
Three piglets from group Wien-BKI and two piglets from group Wien-Ctrl were sacrificed on SD 9 for collection of samples for histopathology. In addition, one piglet from group Wien-Ctrl was found dead on SD 11. Only those piglets that completed the study were included in the analysis of efficacy.