Table 4.
Concentrations of BKI 1369 and its metabolites, BKI 1318 (metabolite 1) and BKI 1817 (metabolite 2) in piglets infected with Wien-I strain; dpi: days post-infection.
| Sample type and time of collection | No. of samples | Drug concentration (μM) | ||
| BKI 1369 | BKI 1318 | BKI 1817 | ||
| Plasma | ||||
| 2 dpi (0 h before 1st dose) | 6 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
| 3 dpi (2 h after 1st dose) | 6 | 4.9 ± 2.0 | 0.01 ± 0.01 | 0 ± 0 |
| 7 dpi (2 h before 9th dose) | 6 | 11.7 ± 4.8 | 0.2 ± 0.1 | 0.2 ± 0.01 |
| 7 dpi (2 h after 9th dose) | 6 | 10.2 ± 2.9 | 0.1 ± 0.1 | 0.02 ± 0.01 |
| 29 dpi (termination) | 6 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
| Urine | ||||
| 29 dpi (termination) | 5a | 0 ± 0 | 0 ± 0 | 0 ± 0 |
a
Urine sample of one piglet could not be obtained.