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. Author manuscript; available in PMC: 2020 Apr 5.
Published in final edited form as: J Mol Biol. 2019 Mar 13;431(8):1650–1670. doi: 10.1016/j.jmb.2019.03.008

Figure 2.

Figure 2.

Enrichment in Gene Ontology terms for proteins with different abundance levels and intrinsic disorder contents.

The first column lists the biological process (BP) terms of the Gene Ontology [56,57] for which statistically significant enrichments were obtained. The number of S. cerevisiae proteins with the corresponding BP term in the reference dataset is indicated in parentheses. The last 4 columns represent the heat maps of the computed statistically significant enrichment levels for each of the listed BP terms among proteins in the following 4 categories respectively. Proteins among the 33.3 percentile most abundant and least abundant proteins, respectively (columns 2 and 3); the subset of proteins from each of the previous categories with high ( ≥ 30%) and low (<10%) IDR content, respectively (columns 4 and 5). The number of proteins in each of the 4 categories is listed at the bottom. The Biological Process (BP) Gene ontology (GO) terms are those from the GO slim yeast ontology in the BiNGO [84] application for Cytoscape [85] with all possible evidence codes. Enrichments were computed using as reference, all S. cerevisiae proteins with available GO annotation and abundance levels of at least 2 ppm (4900 proteins in total). The statistical significance of the computed enrichment was evaluated using the hypergeometric test with Benjamin and Hochberg false discovery rate (FDR) multiple testing correction [93].