Table 4B.

Generalized Estimating Equations Model for longitudinal binary data of grade 2–4 skeletal pain and grade 2–4 body symptoms at 1 month, 6 month, and 1 year post-donation. (Skeletal pain represents pain in at least one of the following sites: back, bone, headache, hip, joints, limbs, and neck. The severity of skeletal pain is defined as the maximum grade among these pain sites. Body symptoms include fever in absence of infections, fatigue, skin rash, injection site reaction, nausea, vomiting, anorexia, insomnia, dizziness, and syncope. The toxicity level is defined as the maximum grade among these symptoms.)

Variable	OR	95% CI	p-value
Skeletal pain
Donor age at donation			0.022
18 to 40	1.00
41 to 60	1.71	(1.12–2.60)	0.013
61 and older	1.65	(1.03–2.66)	0.038
Donor sex
Male	1.00
Female	1.51	(1.16–1.96)	0.002
Comorbidity			0.005
Absent	1.00
Present-accept	1.19	(0.78–1.81)	0.419
Present-indeterminate	1.39	(0.99–1.93)	0.054
Present-defer	2.41	(1.55–3.75)	<0.001
Pre-donation skeletal pain
Grade 0	1.00
Grade 1–4	2.89	(2.21–3.79)	<0.001
Time post-donation			0.006
1 month	1.00
6 months	1.30	(1.05–1.61)	0.016
1 year	1.43	(1.14–1.80)	0.002
Body symptoms
Donor age at donation			0.331
18 to 40	1.00
41 to 60	1.19	(0.75–1.89)	0.455
61 and older	0.89	(0.51–1.55)	0.687
Donor sex
Male	1.00
Female	2.37	(1.66–3.39)	<0.001
Pre-donation skeletal pain
Grade 0	1.00
Grade 1–4	1.67	(1.15–2.41)	0.007

Abbreviations: OR is odds ratio; CI is confidence interval