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. 2019 Apr 8;9:5757. doi: 10.1038/s41598-019-42077-1

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© The Author(s) 2019, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Morphology and mechanical properties of fibroblasts and cancer cells. (a) F-actin (SiR-actin) structure in NIH 3T3 and MDA-MB-231 cells, the height is colour coded with respect to the scaling shown in the colour scale bars. Vertical cross-sections along the marked lines shows that F-actin is mostly localized in the submembranous region (CellMask staining for plasma membrane). Scale bars 10 μm in the horizontal direction and 2 μm in the vertical direction. (b) Box plots of cell height, Young’s relaxation modulus scale factor E₁, and power-law exponent α. The differences between all distributions are significant at the p < 0.001 level.