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. 2019 Apr 8;5:12. doi: 10.1038/s41378-019-0050-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a SEM image of base pore patterns with 150 μm pitch between the pores. The average diameter of the pores was 3.6 ± 0.1 μm so that they are visible under a microscope. b An enclosed nanopore device consisting of an SU-8 nanopore membrane sandwiched by two PDMS chips with a microchannel in a cross configuration. c Optical image of a single base pore located in the crossed area of the two microchannels. d A schematic of the setup for DNA translocation experiments. λ-DNA passes through the nanopore from the lower to upper channels (not to scale). SEM, scanning electron microscopy