Table 1.

Sentinel SNPs associated with SUA in Japanese as identified in the meta-analysis

SNP	Locus	Chr	Position	Gene	Alleles		EAF	Betaa ± SE	P value	I 2
					Effect	Noneffect
Novel loci
rs74896528	1p35.3	1	28598287	SESN2	T	C	0.057	−0.057 ± 0.010	8.42 × 10−9	0
rs10188118	2p25.3	2	653623	LOC105373352, TMEM18	C	G	0.864	0.035 ± 0.006	8.60 × 10−9	48.7
rs6774054	3q25.1	3	149211699	TM4SF4	A	G	0.337	0.024 ± 0.004	1.58 × 10−8	0
rs11952102	5q35.3	5	176740704	MXD3, LMAN2	A	G	0.448	0.022 ± 0.004	4.24 × 10−8	0
rs16898823	6p21.33	6	31106606	PSORS1C1, PSORS1C2	A	T	0.900	0.037 ± 0.007	2.55 × 10−8	0
rs8024067	15q26.1	15	93439224	LINC01578	T	G	0.158	−0.034 ± 0.006	8.41 × 10−9	40.9
rs6031598	20q13.12	20	43056149	HNF4A	T	G	0.378	−0.023 ± 0.004	2.90 × 10−8	27.5
rs2281293	22q13.31	22	44334842	PNPLA3	T	C	0.559	0.024 ± 0.004	4.99 × 10−9	0
Loci also identified by BBJ 28
rs811372	2p15	2	61429568	USP34	T	C	0.367	0.026 ± 0.004	7.97 × 10−10	4
rs10857147	4q21.21	4	81181072	PRDM8, FGF5	A	T	0.699	0.032 ± 0.005	1.31 × 10−11	17.2
rs13230625	7p22.3	7	1286244	UNCX, MICALL2	A	G	0.318	0.027 ± 0.004	4.82 × 10−10	0
rs7835379	8q22.1	8	95975080	TP53INP1, NDUFAF6	A	G	0.755	0.032 ± 0.005	7.41 × 10−12	46.6
rs9416703	10q21.1	10	60283008	BICC1	A	C	0.525	−0.036 ± 0.004	1.70 × 10−18	0
rs11202346	10q23.2	10	88908912	FAM35A	T	G	0.225	0.035 ± 0.005	4.12 × 10−12	0
rs1886603	10q26.11	10	119482303	EMX2, RAB11FIP2	A	G	0.374	0.027 ± 0.004	3.22 × 10−11	0
rs2220970	11p15.4	11	9857749	SBF2	A	G	0.342	0.024 ± 0.004	1.12 × 10−8	0
rs963837	11p14.1	11	30749090	MPPED2, DCDC1	T	C	0.656	0.028 ± 0.005	8.41 × 10−10	5.6
rs6026578	20q13.32	20	57463472	LOC101927932	C	G	0.278	0.028 ± 0.005	5.48 × 10−10	0
Loci also identified by other studies
rs1797052	1q21.1	1	145727683	PDZK1	T	C	0.185	0.041 ± 0.005	2.57 × 10−15	0
rs4072037	1q22	1	155162067	MUC1	T	C	0.828	−0.048 ± 0.005	6.93 × 10−20	62.7
rs1260326	2p23.3	2	27730940	GCKR	T	C	0.559	0.036 ± 0.004	7.56 × 10−19	0
rs16856823	2q31.1	2	170200452	LRP2	A	T	0.808	−0.039 ± 0.005	6.61 × 10−14	0
rs6445559	3p21.1	3	53099466	SFMBT1, RFT1	A	G	0.561	0.029 ± 0.004	2.53 × 10−12	2.6
rs7679724	4p16.1	4	9985376	SLC2A9	T	G	0.586	0.130 ± 0.004	1.67 × 10−224	81.6
rs4148155	4q22.1	4	89054667	ABCG2	A	G	0.705	−0.115 ± 0.004	2.05 × 10−149	0
rs2762353	6p22.2	6	25794431	SLC17A1	A	G	0.160	−0.054 ± 0.005	8.68 × 10−24	11.5
rs9394948	6p21.1	6	43334755	ZNF318	A	C	0.341	0.032 ± 0.004	1.65 × 10−13	9
rs17145750	7q11.23	7	73026378	MLXIPL	T	C	0.102	−0.038 ± 0.007	5.85 × 10−9	0
rs1828911	8q21.11	8	76462547	HNF4G	T	C	0.575	−0.038 ± 0.004	8.08 × 10−21	0
rs57633992	11q13.1	11	64424967	NRXN2	A	C	0.054	−0.668 ± 0.010	<1 × 10−300	68.8
rs79105258	12q24.12	12	111718231	CUX2	A	C	0.254	−0.078 ± 0.005	1.91 × 10−56	0
rs73436803	15q24.2	15	75619201	GOLGA6D, COMMD4	T	C	0.099	−0.043 ± 0.008	1.38 × 10−8	0
rs4966024	15q26.3	15	99295570	IGF1R	A	G	0.486	−0.033 ± 0.004	4.43 × 10−16	0
rs244423	16q22.1	16	69610002	NFAT5	A	G	0.156	0.035 ± 0.006	2.00 × 10−10	40.5
rs73575095	16q23.2	16	79750332	MAF, MAFTRR	T	C	0.719	0.035 ± 0.005	4.03 × 10−15	0
rs9895661	17q23.2	17	59456589	BCAS3	T	C	0.475	0.044 ± 0.005	9.20 × 10−23	0

Chr chromosome, SUA serum uric acid

^aThe beta value represents change in z-score per effect allele copy for the SNP