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. 2019 Apr 8;9:5775. doi: 10.1038/s41598-019-42241-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in end-expiratory lung volume (EELV) and regional ventilation. (A) Ventilator-measured changes of EELV during the bolus of normal saline and induced by the PEEP steps together with the estimated EELV changes calculated from the EIT data. The solid black bar represents the decrease of EELV during the administration of normal saline (ΔEELV_bolus,meas). The dotted black bar represents the respective change of EELV estimated from the EIT data (ΔEELV_bolus,equiv). (B) Differences in regional ventilation caused by the PEEP steps and by the bolus of normal saline. Statistically significant differences (Wilcoxon’s test for the EELV data, Friedman’s test with Tukey’s post hoc analysis for the regional ventilation data, p < 0.05) are denoted with *. The error bars represent standard deviation.