Table 2.
Clinical and biological data at Day 1
| All patients (n = 214) | No brain death (n = 172) | Brain death (n = 42) | p | |
|---|---|---|---|---|
| Hemodynamics | ||||
| MAP, mmHg | 78 (65–91) | 80 (65–92) | 73 (63–82) | 0.09 |
| Heart rate, bpm | 100 (85–114) | 98 (82–112) | 110 (95–119) | < 0.01 |
| Vasoactive drugs | 107 (50) | 74 (43) | 33 (79) | < 0.01 |
| Temperature | ||||
| Temperature, °C | 37.4 (36.2–38.2) | 37.5 (36.4–38.1) | 37.5 (36.1–38.7) | 0.80 |
| TTM | 102 (48) | 81 (47) | 21 (50) | 0.86 |
| Continuous sedation | 88 (41) | 75 (44) | 13 (31) | 0.16 |
| Neurological examination | ||||
| GCS score | 3 (3–4) | 3 (3–5) | 3 (3–3) | < 0.001 |
| GCS Motor subscore ≤ 2 | 181 (85) | 139 (81) | 42 (100) | < 0.001 |
| Myoclonus | 68 (32) | 67 (39) | 1 (2) | < 0.001 |
| Pupillary light reflex present | 112 (52) | 110 (64) | 2 (5) | < 0.001 |
| Spontaneous ventilation absent | 75 (35) | 45 (26) | 30 (71) | < 0.001 |
| Biological variables | ||||
| Arterial pH | 7.25 (7.14–7.32) | 7.25 (7.15–7.33) | 7.17 (7.07–7.29) | 0.02 |
| PaCO2, KPa | 5.3 (4.5–6.5) | 5.3 (4.6–6.5) | 5.4 (4.4–7.0) | 0.97 |
| Serum lactate, mmol/l | 7.7 (4.9–11.0) | 7.4 (4.5–10.7) | 8.9 (5.8–12.0) | 0.07 |
| Troponin, µg/l | 0.7 (0.1–5.1) | 0.5 (0.1–3.6) | 1,9 (0.3–19.0) | < 0.01 |
| ALT, IU/L | 104 (44–261) | 84 (39–206) | 178 (92–376) | < 0.001 |
| Creatinine, µmol/l | 110 (81–173) | 107 (80–172) | 124 (87–178) | 0.33 |
| Platelets, 109/l | 201 (155–256) | 208 (157–261) | 181 (144–242) | 0.29 |
| SOFA score | 9 (6–12) | 9 (6–11) | 11 (9–14) | < 0.001 |
| SAPS II | 74 (65–86) | 75 (64–86) | 74 (69–86) | 0.91 |
Data are expressed as median (interquartile range) or number (%)
MAP mean arterial pressure, TTM targeted temperature management, GCS Glasgow Coma Scale, PaCO2 arterial partial pressure of carbon dioxide, ALT alanine aminotransferase, SOFA Sequential Organ Failure Assessment, SAPS II Simplified Acute Physiology Score II