Table 3.
Characteristics of the included studies
| Included studies | Clear inclusion and exclusion criteria | Randomization method | Assessment parameters (two or more)/validated measurements | Duration of study | With/without carrier and route | Risk of bias |
|---|---|---|---|---|---|---|
| Vaziri et al. 2007 | ✓ | No | 2 | 4 weeks | No carrier/injection | Low |
| Killeen et al. 2012 | ✓ | No | 1 | 48 days | Systemic/local injection | Low |
| Kilic et al. 2008 | ✓ | No | 2 | 14 days | Systemic/local | Low |
| Rutledge et al. 2011 | ✓ | No | 1 | 60 days | Local injections | Low |
| Ozec et al. 2007 | ✓ | No | 2 | 14 days | Systemic | Low |
| Sherif et al. 2016 | ✓ | No | 1 | 4 weeks | Topical | Low |
| Wu Z et al. 2008 | ✓ | No | 2 | 12 weeks | Local | Low |
| Anbinder et al. 2007 | ✓ | Yes | 1 | 35 days | Oral | Low |
| George MD et al. 2013 | ✓ | No | 1 | 30 days | Injections/carrier | Low |
| Holwegner et al. 2015 | ✓ | No | 2 | 28 days | Injections/carrier | Low |
| Gouda et al. 2017 | ✓ | No | 2 | 9 months | Local | Low |
| Ranjan et al. 2017 | ✓ | No | 2 | 9 months | Local | Low |
| Kinra et al. 2010 | ✓ | No | 2 | 24 weeks | Local | Low |
| Chauhan et al. 2015 | ✓ | No | 2 | 3 months | Local | Low |
| Pradeep et al. 2012 | ✓ | No | 2 | 6 months | Local | Low |
| Madi and Kassem. 2018 | ✓ | No | 2 | 14 days | Topical | Low |