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. 2019 Apr 2;9:216. doi: 10.3389/fonc.2019.00216

Figure 3.

Figure 3

HPSE promotes the proliferation of CRC cells in vivo. Cells were injected subcutaneously into the back of BALB/c nude mice. Mice were sacrificed at 3 weeks after transplantation. The xenografts were excised and weighted. (A) Knockdown of HPSE expression inhibited tumorigenicity of SW480 cells in BALB/c nude mice (n = 6). The weight of tumors originating from SW480-NC is larger than that arising from SW480-KD1 and SW480-KD2 cells (left panel). A representative photograph of tumor size is shown (right panel). (B) Overexpression of HPSE in SW620 cells promoted the growth of mouse xenograft tumors (n = 6). Scale bar, 1 cm. Immunohistochemistry analysis of HPSE and Ki-67 expression in xenografts originating from (C) SW480 and (D) SW620 cells. Scale bar, 100 μm. Quantification of tumor cell proliferation in (E) SW480 and (F) SW620 xenografts using Ki-67 staining (n = 6). Data are expressed as Ki-67 positive tumor cells as percentage of total tumor cells. *p < 0.05, ***p < 0.001.