Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 2;9:216. doi: 10.3389/fonc.2019.00216

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Liu, Zhou, Li, Zhang, Li, Zhou and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Knockdown of HPSE inhibits CRC cells invasion in vitro and liver metastasis in vivo. (A) An invasion assay was performed in a Matrigel-coated transwell chamber; representative images of invasion assay are shown. (B) The invasive ability of SW480 cells was inhibited by HPSE knockdown (n = 5). (C) SW480 cells were injected into the spleens of BALB/c mice. After 6 weeks, the mice were sacrificed, and their livers were fixed. Microscopic liver metastases were detected by H&E staining. (D) The metastatic foci were counted (n = 4). HPSE knockdown in SW480 cells resulted in fewer metastatic foci in the liver. ^*p < 0.05, ^***p < 0.001.