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. 2019 Apr 2;13:272. doi: 10.3389/fnins.2019.00272

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Copyright © 2019 Xu, Li, Zhang, Schluesener and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oridonin treatments attenuated cellular infiltration in spinal roots and inflammatory microglial activation in lumbar spinal cords of EAN rats. EAN Rats were preventively treated with Oridonin and sacrificed on Day 15, spinal cords were taken for immunohistochemical staining and analyzed, especially focusing on lumbar sections. Significant accumulation of ED1⁺ and W3/13⁺ cells was mainly observed in dorsal roots of our EAN rats (A,B). Similar to sciatic nerves, they were mainly detected to concentrate around vessels in perineurium and endoneurium. Following the Oridonin treatment, their accumulations were significantly reduced (D,E,G,H). The expression of ED1 in lumbar spinal cords was further analyzed. In lumbar spinal cords of EAN rats, significantly increased ED1 expression could be observed in the control group (C). ED1 IR was mainly detected in gray matter, particularly in the superficial layers of dorsal horns. The density of ED1 IR in dorsal horns was then investigated, and it was significantly decreased by Oridonin treatment (F), compared to the control group (I). ^∗p < 0.05, ^∗∗p < 0.01 compared to the control group, n = 6.