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Schematic diagram of TET2 function in DNA repair. TET2 knock-down results in lower expression of Lig4 and BRCA2 expression, and SIRT1 deficiency results in Ku70 and TET2 inactivation, blocking the NHEJ and HR repair. If combined with inhibition of PARP inhibitor in SSB repair, the whole DNA repair pathways are harmed, cell survival gets impeded, and cell apoptosis is elevated.
