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. 2019 Apr 2;13:97. doi: 10.3389/fncel.2019.00097

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Copyright © 2019 Kyle, Wu, Gourzi and Tsirka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Remaining microglia have no change in rate of replication after PLX5622 treatment. BrdU⁺Iba1⁺ cells were quantified (A, F_(2,15) = 30.39, p < 0.0001) and normalized in (B, F_(2,15) = 51.75, p < 0.0001). The OB contained more BrdU⁺ microglia than the RMS and SVZ in control mice, but only more than the SVZ in PLX5622 treated mice. When normalized, control OBs had a higher percentage of BrdU⁺ microglia compared to the RMS and SVZ, with no significant difference between control and PLX5622 treated mice. ^& = comparison between regions within treatment, * = comparison between treatments within a region. */^& = p < 0.5; **/^&& = p < 0.01; ***/^&&& = p < 0.001. n = 6 for all groups, two sections per n. Microglia in (A) plotted as an average per section generated by sum of field of views.