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. 2019 Apr 2;13:97. doi: 10.3389/fncel.2019.00097

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Copyright © 2019 Kyle, Wu, Gourzi and Tsirka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment with PLX5622 has no effect on microglia proliferation. Representative images of the SVZ, RMS, and OB from 14d of PLX5622 treatment (A), with the dashed line separating the SVZ from the lateral ventricle. DAPI in blue, Iba1 in green, Ki67 in gray. Quantification of microglia ablation shown in (B, F_(2,15) = 55.46, p < 0.0001). Ki67⁺Iba1⁺ cells were counted (C, F_(2,15) = 64.52, p < 0.0001) and normalized (D, F_(2,15) = 12.77, p = 0.0006). Similar to the BrdU data, the OB contained more Ki67⁺ microglia than the RMS and SVZ in both control and PLX5622 treated mice. Total Ki67⁺ cells from the SVZ and RMS were quantified in (E, F_(2,15) = 0.11, p = 0.74). & = comparison between regions within treatment, ^& = p < 0.5; ^&& = p < 0.01; ^&&& = p < 0.001. n = 6 for all groups.