Fig. 2.

EpoL treatment restored calcium homeostasis in neuronal cells exposed to Aβ. (A) Hippocampal neurons were treated for 24 h with oligomers of Aβ₄₀ and co-incubated with Epo or EpoL at neuroprotective concentrations, as represented in the scheme on the top part of figure. (B) Quantification of percentage frequency of calcium transients using Fluo4AM loaded cells treated for 24 h with the different treatments. (C) Representative images of calcium transients over a 200 s period in cells exposed to the different indicated treatments. Values are mean ± SEM, n = 3 using one-way ANOVA and Dunns test. ***:p < 0.001; ****:p < 0.0001 versus neuronal cells treated with Aβ; ++++:p < 0.0001 versus control cells; ###:p < 0.001; ####:p < 0.0001 versus EpoL or Epo treatment.