Fig. 6.
Neuroprotective effect of EpoL in hippocampal organotypic cultures against stress induced by chronic treatments of Aβ. (A) Epifluorescence images of hippocampal organotypic cultures treated for 4 days with Aβ25-35 (0.5 μM) and co-incubated with EpoL or Epo at neuroprotective concentrations. (B) Representative fluorescence images of PI/Hoechst signal of the CA1 region. Values are mean ± SEM, n = 5 using one-way ANOVA and Tukey test. ****:p < 0.0001 versus neuronal culture treated with Aβ; ++++:p < 0.001 versus control cells; ###:p < 0.001 versus Epo treatment.