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. 2019 Apr 2;10:342. doi: 10.3389/fphys.2019.00342

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Copyright © 2019 De Maria, Bari, Cairo, Vaini, Esler, Lambert, Baumert, Cerutti, Dalla Vecchia and Porta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The grouped error bar graphs show cBRS (A–C) and sBRS (D–F) in young healthy subjects undergoing incremental head-up tilt as a function of the experimental condition (i.e., T0, T20, T30, T40, and T60). cBRS and sBRS were estimated using three different approaches, namely SEQ (A,D), PRSA (B,E), and nPRSA (C,F) methods, and reported by separately considering positive (black bars) and negative (white bars) SAP variations in (A–C) and DAP changes in (D–F). The results are presented as mean plus standard deviation. The symbol # indicates a significant change of cBRS (A–C), or sBRS (D–F), versus positive AP variations with p < 0.05 within the same experimental condition (i.e., T0, T20, T30, T40, or T60). The symbol ^∗ indicates a significant change with p < 0.05 versus T0 within the same type of cBRS (A–C), or sBRS (D–F).