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. 2019 Apr 2;10:330. doi: 10.3389/fphar.2019.00330

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Copyright © 2019 Doan, Musa, Candeias, Emmert-Streib, Yli-Harja and Kandhavelu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Selected results of Gene Ontology terms and pathways over-representation analysis (FDR < 0.01) on the top 20 terms. (A) Overrepresented Gene Ontology (GO) Biological process terms. (B) Overrepresented GO Molecular function terms. (C) Overrepresented KEGG pathway terms. The x-axis contains the number of genes involved in a particular pathway that were found differentially expressed in our study. The pie charts indicate the fraction of the signature genes associated with significantly enriched terms. The number of genes were normalized to allow comparisons between groups within the same cell line, and the vertical line on the pathways corresponds to the significant p-values. (D) The top 20 DEGs which are involved in the DNA damage on LN229 and Snb19. The DEGs were color coded, with the colors corresponding to the up- and down- expressed.