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. 2019 Apr 2;10:666. doi: 10.3389/fimmu.2019.00666

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Copyright © 2019 Xu, Huang, Hou, Kwok, Laga, Wang, Ma, Sun and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network plot showing Spearman's correlation between the differentially bacteria and feed intake, body weight, immune indexes in (A) elderly dogs, (B) training dogs and (C) young dogs. Blue circles and red diamonds represent significantly correlated bacteria and physiological indices (feed intake, body weight, fecal secretory IgA, serum IgG, IFN-α, IL-6, and TNF-α), respectively. The size of the red diamonds corresponds to the number of significantly correlated bacteria. Significant correlations between the bacteria and immune factors, feed intake, body weight are connected by curve; the color of the curve lines represents the correlation strength as illustrated by the color scheme. The color scheme representing the Spearman's rho ranks between 0.6 and −0.6. Positive and negative Spearman's rho represent positive and negative correlation, respectively.