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. 2019 Apr 2;10:305. doi: 10.3389/fgene.2019.00305

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Copyright © 2019 Shan, Chen and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DEGs shared in three independent microarray datasets and their potential functions. A total of 125 upregulated genes (A) and 252 downregulated genes (B) were shared between the GSE98383, GSE89377, and GSE17548 datasets when comparing HCC to cirrhosis subjects. Red indicates upregulation and blue represents downregulation. DEGs were determined using GEO2R software. FDR < 0.05 and FC > 1.5 were considered as the cutoff values. (C) Significantly enriched KEGG pathways of the total shared DEGs. ClusterProfiler package was selected to perform KEGG pathway enrichment analysis. Adjusted P-values of <0.05 were considered statistically significant.