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Schematic Showing rAAV Entry, Movement within Cytoplasm, Attachment with DNA, and Integration with DNA Segment for Possible Genome Modification
The steps include the following: (1) entry of rAAV into cell, (2) uptake by exosome and transport within cytoplasm, (3) release of rAAV for entry into nucleus, (4) rAAV delivery of homing endocnulease (HE) and desirable DNA segment, (5) HE cut of the non-desirable DNA code, and (6) rAAV-delivered desirable DNA code replacement of the DNA.
