Table 3.

Clinical and Research Applications across Important Genome-Editing Techniques

Serial No.	Parameter	ZFN	TALEN	CRISPER/Cas	Reference
1	diagnostic utility	+	+	+++	60
2	clinical trial use	++	+	+++	61
3	utility as epigenetic marker	++	+++	++++	62
4	making gene-knockout models for research	no	no	yes (CRISPRi)	63
5	capacity for modification of mitochondrial DNA	no	no	probable	64
6	genetic editing in human babies	no	no	yes	65
7	RNA editing	no	no	yes	66