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. 2019 Apr 2;12:75. doi: 10.3389/fnmol.2019.00075

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Copyright © 2019 Tao, Li, Wen, Song, Wei, Du, Yang, Xu and You.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In situ RNA hybridization of Sst, Erbb4 and Npas1. (A–D) Sst mRNA expression was increased in the E15.5 neocortex (arrows) and ventral telencephalon (arrows) of mutants. More Sst⁺ cells were found in the ventral telencephalon of double mutants than single mutants and controls (arrows). (E–I) Abnormal migration of Erbb4⁺ cells (PV⁺ immature cortical interneurons) in mutant mice. Double mutants appeared to have relatively more Erbb4⁺ cells in the cortical SVZ (arrows) and in the ventral telencephalon (arrows) and relatively fewer Erbb4⁺ cells in the cortical marginal zone (MZ; arrowheads). (J–M) Decreased Npas1⁺ cells in the cortical MZ (arrowheads) and increased Npas1⁺ cells in the cortical SVZ (arrows) were observed in double mutants compared to single mutants and controls. *P < 0.05; **P < 0.01; ***P < 0.001. Scale bar: 200 μm in (A) for (A–C,E–G,J–L).