Table 3.
(A) Types of EGFR mutations in Turkish NSCLC patients.
Mutation | Exon | Nucleotide Number | Amino Acid Changes | Mutation |
---|---|---|---|---|
Point mutation | 18 | 2155 (G>T) | G719C | 1 (0.8%) |
Point mutation | 18 | 2134 (G>A) | G719S | 3 (2.5%) |
Point mutation | 18 | 2155 (G>A) | G719A | 9 (7.6%) |
Deletion | 19 | 235-2249del (GGA ATT AAG AGA AGC) | delE746-A750 | 39 (33.4%) |
Del/Ins | 19 | 2235-2252del (GGA ATT AAG AGA AGC insCA) | L747-6751insP | 10 (8.5%) |
Del/Ins | 19 | 2235-2252del (GGA ATT AAG AGA AGC insAAT) | delE746-T751insI | 5 (4.2%) |
Del/Ins | 19 | 2235-2258del (GGA ATT AAG AGA AGC insAAT CCA) | delE746-A750insIP | 1 (0.8%) |
Del/Ins | 19 | 2235-2249del (GGA ATT AAG AGA AGC insAGA) | delL747-P753insS | 3 (2.5%) |
Del/Ins | 19 | 2235-2258del (GGA ATT AAG AGA AGC insAAT) | delE746-A750insI | 3 (2.5%) |
Del/Ins | 19 | 2235-2258del (GGA ATT AAG AGA AGC insCCA) | delA746-A750insP | 1 (0.8%) |
Del/Ins | 19 | 2235-2258del (GGA AAT AAG AGA AGC insCAA) | delL747-T751insQ | 1 (0.8%) |
Point mutation | 20 | 2369 (C>T) | T790M | 3 (2.5%) |
Point mutation | 21 | 2573 (T>G) | L858R | 10 (8.5%) |
Point mutation | 21 | 2582 (T>A) | L861Q | 29 (24.6%) |
Del/Ins: deletions and insertions.