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. 2019 Apr 2;10:324. doi: 10.3389/fphys.2019.00324

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Copyright © 2019 Yellowhair, Newville, Noor, Maxwell, Milligan, Robinson and Jantzie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CXCR2 Antagonism Improves Gray Matter Microstructural Integrity. Following prenatal chorioamnionitis (CHORIO), transient postnatal administration of the CXCR2 antagonist, SB225002, attenuated injury induced changes in fractional anisotropy (FA) in the hippocampus (A) at postnatal day 21 (P21). While CHORIO reduced FA in the thalamus, no difference was observed with CXCR2 antagonism in the thalamus (B). (n = 5–6, two-way ANOVA with Bonferroni’s post hoc correction, ^∗p < 0.05, ^∗∗p < 0.01).