Figure 4.

Three-dimensional response surfaces created using the Geometric Framework for Nutrition. The relationships between the macronutrients and four nutrient-sensing genes [(A) Mtor, (B) Igf1, (C) Pkrab2, (D) Fgf21] are demonstrated. The response surfaces vary from red, which is the highest value, to blue, which is the lowest value. The axes show the food intake in kilojoule per mouse per day. Each of the three surfaces shows the interaction between two macronutrients at the median value of the other macronutrient. The GAMS statistics are shown in Supplementary Table 5.