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A proposed biomarker panel for genetic diagnosis and developing treatments. (A) Signature genes, identified by stringent expression filtering (Cntl < 10 CPM, Hurler > 30 CPM and DE > 16-fold) and based on pathways investigated in Figures 4–7. Genes indicated in bold were validated by qRT-PCR. (B) Validation of selected top candidate signature genes by qRT-PCR.
