Table 3.

Adjusted HRs for study outcomes in the CKD subgroup according to SMg tertiles (mg/dL)

	Model 1			Model 2			Model 3
	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
All-cause death
Low SMg	2.22	1.33–3.72	0.002	1.92	1.03–3.60	0.04	2.31	1.23–4.36	0.01
Medium SMg	0.97	0.55–1.72	0.92	0.91	0.45–1.84	0.80	1.15	0.55–2.41	0.71
High SMg	Ref.	—	—	Ref.	—	—	Ref.	—	—
CV death or event
Low SMg	1.47	0.85–2.57	0.17	1.16	0.62–2.18	0.64	0.97	0.50–1.89	0.93
Medium SMg	0.89	0.49–1.61	0.69	0.67	0.33–1.37	0.27	0.52	0.24–1.12	0.09
High SMg	Ref.	—	—	Ref.	—	—	Ref.	—	—

SMg, serum magnesium; CV, cardiovascular; HR, hazard ratio; 95% CI, 95% confidence interval.

HR of the low versus high tertile of SMg level. eGFR was calculated according to the MDRD study equation. CKD was defined as eGFR <60 mL/min/1.73 m² and/or ACR >17 mg/g in men and >25 mg/g in women.

Model 1 was adjusted for age, gender and race/ethnicity. Model 2 was adjusted for variables in Model 1 plus BMI, serum phosphorus, calcium, bicarbonate, albumin, iPTH, total cholesterol and HDL. Model 3 was adjusted for variables in Model 2 plus eGFR, prevalent hypertension, prevalent type 2 diabetes, and use of diuretics and dietary supplements.