Table 4.

Adjusted HRs for study outcomes in the non-CKD subgroup according to SMg tertiles (mg/dL)

	Model 1			Model 2			Model 3
	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
All-cause death
Low SMg	2.09	1.47–2.98	<0.001	1.54	1.03–2.33	0.04	1.30	0.86–1.96	0.22
Medium SMg	1.38	0.99–1.92	0.06	1.26	0.88–1.82	0.21	1.24	0.86–1.79	0.25
High SMg	Ref.	—	—	Ref.	—	—	Ref.	—	—
CV death or event
Low SMg	1.29	0.91–1.84	0.16	1.22	0.83–1.79	0.31	1.06	0.72–1.57	0.77
Medium SMg	1.06	0.78–1.44	0.69	0.99	0.71–1.37	0.95	1.01	0.73–1.41	0.94
High SMg	Ref.	—	—	Ref.	—	—	Ref.	—	—

SMg, serum magnesium; CV, cardiovascular; HR, hazard ratio; 95% CI, 95% confidence interval. HR of the low versus high SMg level. eGFR was calculated according to the MDRD study equation. CKD was defined as eGFR <60 mL/min/1.73 m² and/or ACR >17 mg/g in men and >25 mg/g in women.

Model 1 was adjusted for age, gender and race/ethnicity. Model 2 was adjusted for variables in Model 1 plus BMI, serum phosphorus, calcium, bicarbonate, albumin, iPTH, total cholesterol and HDL. Model 3 was adjusted for variables in Model 2 plus eGFR, prevalent hypertension, prevalent type 2 diabetes, and use of diuretics and dietary supplements.