Figure 2.

Statistical analysis of mutable motifs in sites of somatic mutations and surrounding regions. The excess of mutations in motifs was calculated using the ratio Fm/Fn, where Fm is the fraction of somatic mutations observed in a given mutable motif (the number of mutated motifs divided by the number of mutations), and Fn is the frequency of the motif in the DNA neighborhood of somatic mutations (the number of motif positions divided by the total number of all un-mutated positions in the 120 bp window).