TABLE 3.
Unadjusted and adjusted AMH geometric means (95% CIs) according to quartile of total and free 25(OH)D and VDBP: NHS2 (1996–2011)1
| AMH geometric mean (95% CI), ng/mL | ||||
|---|---|---|---|---|
| n | Range | Unadjusted | Adjusted2 | |
| Total 25(OH)D, nmol/L | ||||
| Q1 | 169 | 22.9–52.1 | 0.4 (0.3, 0.6) | 0.5 (0.4, 5.8) |
| Q2 | 175 | 52.2–65.8 | 0.4 (0.3, 0.5) | 0.4 (0.3, 4.6) |
| Q3 | 153 | 65.9–78.8 | 0.4 (0.3, 0.5) | 0.4 (0.3, 5.4) |
| Q4 | 159 | 78.8–159.0 | 0.4 (0.3, 0.5) | 0.4 (0.3, 4.8) |
| P 3 | 0.65 | 0.55 | ||
| Free 25(OH)D, pmol/L | ||||
| Q1 | 177 | 6.8–16.2 | 0.4 (0.3, 0.5) | 0.4 (0.3, 0.5) |
| Q2 | 176 | 16.3–21.4 | 0.4 (0.3, 0.5) | 0.4 (0.3, 0.5) |
| Q3 | 161 | 21.6–27.5 | 0.4 (0.3, 0.5) | 0.4 (0.3, 0.5) |
| Q4 | 142 | 27.5–88.9 | 0.5 (0.4, 0.6) | 0.5 (0.4, 0.6) |
| P 3 | 0.35 | 0.32 | ||
| VDBP, µg/mL | ||||
| Q1 | 137 | 48.7–177.7 | 0.5 (0.4, 0.7) | 0.5 (0.4, 0.7) |
| Q2 | 168 | 178.2–224.3 | 0.4 (0.3, 0.5) | 0.4 (0.3, 0.6) |
| Q3 | 169 | 224.8–272.0 | 0.4 (0.3, 0.5) | 0.4 (0.3, 0.5) |
| Q4 | 182 | 272.6–425.8 | 0.3 (0.3, 0.4) | 0.3 (0.3, 0.4) |
| P 3 | 0.07 | 0.04 | ||
1AMH, anti-Müllerian hormone; MET, metabolic equivalent task; NHS2, Nurses’ Health Study II; Q, quartile; VDBP, vitamin D–binding protein; 25(OH)D, 25-hydroxyvitamin D.
2Multivariable model 1 adjusted for matching factors plus physical activity (<9, 9 to <42, or ≥42 MET-h/wk), duration of breastfeeding at blood draw (0, >0–6, >6–18, or >18 mo), smoking status at blood draw (nonsmoker vs. current smoker), BMI (kg/m2; <25 or ≥25), and intakes of alcohol (0, 0.1–9.9, 10.0–29.9, or ≥30.0 g/d) and percentage of vegetable protein (continuous) at blood draw.
3 P values corresponds to type III P values.