FIGURE 5.

Forest plot of the β estimates (regression coefficients) from the meta-analysis of the association between BMI and relative telomere length (T/S ratio) as the outcome in the “young” pooled population (age ≥18 y and ≤60 y). The unit of the estimates and 95% CI is 10⁻³. A random-effects model was used and adjusted for sex. Statistical heterogeneity was estimated by I² statistics for each of the 12 meta-analyses. The shaded boxes indicate the inverse variance weighting of each estimate, and the size of the box indicates the weight. In case no shaded box is visible, the weight is very small. ACCT, Anglo-Cardiff Collaborative Trial; BASE-II, Berlin Aging Study; CAS, calcific aortic valve stenosis study; CAVASIC, Cardiovascular Disease in Intermittent Claudication; DALS, Diet, Activity and Lifestyle Study; DHS, Dallas Heart Study; EARSII, European Atherosclerosis Study II; ECRAN, Envejecimiento y Enfermedades Crónicas Asociadas a Nutrición (Aging and Nutrition Associated Chronic Diseas); EpiDREAM, Epidemiologic study of the Screenes for DREAM (Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication); ES, estimate; GAHR2, Prospective evaluation of Gender and Age differences in the impact of Hostility and Reactivity on intermediary coronary artery disease risk factors; HBCS, Helsinki Birth Cohort Study; KORA F3, Cooperative Health Research in the Region of Augsburg F3 (2004/2005) survey; KORA F4, Cooperative Health Research in the Region of Augsburg F4 (2006/2008) survey; MDCC, Malmö Diet and Cancer Cohort; MESA, Multi-Ethnic Study of Atherosclerosis (https://www.mesa-nhlbi.org/); MONICA, Multinational Monitoring of Trends and Determinants in Cardiovascular Disease; NESDA, The Netherlands Study of Depression and Anxiety; NESDO, The Netherlands Study of Depression in older persons; Not publ, not published; PATH 40, Personality and Total Health Through Life Project AGE 40–44; PREDIMED, Prevención con Dieta Mediterránea; PREVEND, Prevention of Renal and Vascular End-stage Disease; PRT, Progressive Resistance Training; Ref, reference; RPE, Richard Paul Ebstein; SAPHIR, Salzburg Atherosclerosis Prevention program in subjects at High Individual Risk Study; SWHS, Shanghai Women's Health Study; T/S ratio, telomere-to–single-copy gene ratio; UMED, Uniwersytet MEDyczny w Łodzi (Medical University of Lodz (MUL)); UMS, ultra-marathon study; USKCS, US Kidney Cancer Study; YMCA, Young Men Cardiovascular Association.