Fig. 3.

Loss of Xxylt partially rescues Notch haploinsufficient phenotypes. (A–D) Animals were raised at 25°C. (A) N^55e11/+ animals show wing vein thickening (asterisk) and margin defects (arrowhead). Penetrance of wing vein thickening and wing margin loss is 100% and 39%, respectively. (B) Xxylt^Δcds/+ does not suppress the N^55e11/+ phenotypes. (C) Xxylt^Δcds/Δcds partially rescues the N^55e11/+ phenotypes (penetrance of 79% for wing vein thickening and 27% for wing margin loss). (D) Providing a copy of wild-type Xxylt transgene (PBac{Xxylt^gt-wt-V5}VK20) reverted the rescue of N^55e11/+ phenotypes in an Xxylt^Δcds/Δcds background. (E–H) Animals raised at 30°C show a similar trend.