Skip to main content
. Author manuscript; available in PMC: 2019 Apr 9.
Published in final edited form as: Sci Transl Med. 2018 Aug 29;10(456):eaam6474. doi: 10.1126/scitranslmed.aam6474

Fig. 8. Effects of tenapanor on paracellular macromolecule absorption in rats and on phosphate, sodium, and potassium absorption in healthy human volunteers.

Fig. 8.

(A) Radioactive phosphate and (B) radioactive mannitol absorption in vivo in rats after treatment with vehicle (acidified water, 0.01% Tween 80) or different doses of tenapanor. dpm, disintegrations per minute; AUC, area under the curve. (C) Small intestinal glucose content after initiation of a standardized meal in rats pretreated with vehicle or tenapanor (0.15 mg/kg) or vehicle (acidified water, 0.01% Tween 80) (n = 4 to 7 per group). (D) Stool and (E) urinary phosphorus, (F) urinary sodium, and (G) urinary potassium excretion at baseline (day −1) and after 4 days of tenapanor treatment [15 mg twice daily (b.i.d.)] in healthy volunteers. Means ± SEM (A to C), means ± SD (D to G). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; two-way ANOVA, with post hoc testing at time point with Bonferroni’s correction (A to C); pairwise comparisons by Student’s t test (D to G).