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. 2019 Apr 8;18:47. doi: 10.1186/s12933-019-0853-x

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Mixed comparisons of anti-diabetic agents used among patients at high risk of heart failure by drug class. Agents are reported in order of heart failure risk ranking. Treatment at the top left corner ranks first, while the one at the bottom right corner ranks last. An odds ratio (OR) lower than 1 indicates better safety for heart failure in favor of the column-defining treatment. SGLT2i sodium-glucoseco-transporter 2 inhibitors, GLP1ra glucagon-like peptide-1 receptor agonists, DPP4i dipeptidyl peptidase 4 inhibitors, TZD thiazolidinediones, MET metformin, SU sulfonylureas, PLA placebo