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. 2019 Apr 7;33:2058738419841482. doi: 10.1177/2058738419841482

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — (a) Expression of PI3K in the hippocampus of APP/PS1 transgenic mice was determined by western blotting. (b) Expression of PI3K mRNA was determined by RT-PCR. Control: C57BL/6J mice; APP: APP/PS1 mice; APP + D: donepezil; APP + Gs: GAPT small dose; APP + Gm: GAPT middle dose; APP + Gh: GAPT high dose. *P < 0.05 versus control group, **P < 0.01 versus control group, △P < 0.05 versus model group, △△P < 0.01 versus model group; ANOVA. The PI3K expression in the donepezil- and GAPT-treated groups were all increased (P < 0.05), and there was significant difference between the GAPT middle-dose group and the model group (P < 0.01). The PI3K mRNA expression of the donepezil group and GAPT middle-dose group were increased (P < 0.05).