Table 1.
Preoperative and perioperative data for patients with acute lung injury after pulmonary resection.
| Total (n = 58) |
Early treatment (n = 42) |
Late treatment (n = 16) |
p value | |
|---|---|---|---|---|
| Age, years | 70 (62–72) | 70 (61–72) | 71 (63–74) | 0.508 |
| Male | 53 (91) | 38 (91) | 15 (94) | 1.0 |
| BMI, kg/m2 | 22.3 (20.2–24.5) | 23.1 (20.2–25.3) | 22.0 (19.3–23.3) | 0.175 |
| Smoking history | 0.905 | |||
| Ex-smoker | 32 (55) | 22 (52) | 10 (63) | |
| Current smoker | 21 (36) | 16 (38) | 5 (31) | |
| ASA physical status | 0.120 | |||
| 1 | 5 (9) | 4 (10) | 1 (6) | |
| 2 | 41 (71) | 32 (76) | 9 (56) | |
| ⩾3 | 12 (21) | 6 (14) | 6 (38) | |
| Comorbidities | ||||
| COPD | 30 (52) | 19 (45) | 11 (69) | 0.146 |
| Interstitial lung disease | 10 (17) | 6 (14) | 4 (25) | 0.439 |
| Hypertension | 24 (41) | 16 (38) | 8 (50) | 0.552 |
| Diabetes mellitus | 18 (31) | 15 (36) | 3 (19) | 0.342 |
| Other malignancies | 10 (17) | 7 (17) | 3 (19) | 1.0 |
| Pulmonary function test | ||||
| FEV1 % predicted postoperative | 63 (54–75) | 65 (55–75) | 60 (51–75) | 0.596 |
| DLCO % predicted postoperative | 51 (44–61) | 53 (46–63) | 48 (38–51) | 0.070 |
| Clinical stage | 0.465 | |||
| I | 22 (38) | 18 (43) | 4 (25) | |
| II | 21 (36) | 14 (33) | 7 (44) | |
| III | 15 (26) | 10 (24) | 5 (31) | |
| Neoadjuvant treatment | 11 (19) | 5 (12) | 6 (38) | 0.055 |
| Side of operation | 0.877 | |||
| Right | 36 (62) | 25 (60) | 11 (69) | |
| Left | 20 (35) | 15 (36) | 5 (31) | |
| Approach type | 0.217 | |||
| Open thoracotomy | 39 (67) | 26 (62) | 13 (81) | |
| Minimal invasive surgery | 19 (33) | 16 (38) | 3 (19) | |
| Type of operation | 0.767 | |||
| Partial resection | 4 (7) | 3 (7) | 1 (6) | |
| Lobectomy | 43 (74) | 32 (76) | 11 (69) | |
| Bilobectomy | 4 (7) | 2 (5) | 2 (13) | |
| Pneumonectomy | 7 (12) | 5 (12) | 2 (13) | |
| Total operation time, min | 254 (180–318) | 236 (178–337) | 265 (221–300) | 0.626 |
| One lung ventilation time, min | 134 (100–199) | 133 (100–199) | 150 (113–229) | 0.565 |
| Peak airway pressure, cmH2O | 21 (18–23) | 21 (18–23) | 21 (17–25) | 0.643 |
| Tidal volume, ml | 398 (364–424) | 400 (378–427) | 368 (344–421) | 0.095 |
| Intraoperative volume infusion, ml | 1750 (1238–2108) | 1725 (1250–2025) | 1750 (965–2200) | 0.931 |
| Transfusion | 6 (10) | 4 (10) | 2 (13) | 0.664 |
| Bleeding, ml | 300 (200–400) | 300 (200–400) | 300 (163–400) | 0.854 |
Data are presented as number (percentage) or as median (interquartile range).
ASA, American Society of Anesthesiologists; BMI, body mass index; COPD, chronic obstructive pulmonary disease; DLCO, diffusing capacity for carbon monoxide; FEV1, forced expiratory volume in 1 second.