Table 2.
Severity of acute lung injury and treatment modalities in the intensive care unit.
| Total (n = 58) |
Early treatment (n = 42) |
Late treatment (n = 16) |
p value | |
|---|---|---|---|---|
| SOFA score | 4 (2–6) | 4 (2–6) | 5 (2–6) | 0.464 |
| Severity of ALI | ||||
| LIS | 2.0 (1.5–2.5) | 2.0 (1.5–2.5) | 2.0 (1.6–2.3) | 0.833 |
| OI | 10.2 (6.9–14.2) | 10.9 (6.9–13.9) | 9.0 (6.3–15.9) | 0.768 |
| PaO2/FiO2 ratio | 161 (142–207) | 160 (136–215) | 167 (145–201) | 0.770 |
| Laboratory data | ||||
| pH | 7.42 (7.38–7.45) | 7.41 (7.37–7.45) | 7.42 (7.38–7.44) | 0.520 |
| PaO2, mmHg | 77 (66–88) | 76 (65–88) | 79 (68–89) | 0.558 |
| PaCO2, mmHg | 38 (33–42) | 37 (33–42) | 38 (32–45) | 0.902 |
| HCO3, mmol/L | 25 (22–26) | 25 (22–26) | 26 (24–27) | 0.167 |
| CRP, mg/dL | 19.9 (13.7–24.8) | 21.4 (14.4–26.1) | 17.5 (7.9–21.2) | 0.013 |
| Mechanical ventilation | 43 (74) | 30 (71) | 13 (81) | 0.522 |
| FiO2 | 0.5 (0.4–0.6) | 0.5 (0.4–0.6) | 0.5 (0.4–0.6) | 0.571 |
| PEEP, cmH2O | 6 (5–8) | 6 (5–8) | 5 (5–9) | 0.858 |
| Above-PEEP, cmH2O | 14 (12-–15) | 14 (12–15) | 12 (12–16) | 0.337 |
| Tidal volume, ml | 370 (330–490) | 350 (295–460) | 440 (353–570) | 0.112 |
| Corticosteroid | 0.375 | |||
| Low dose | 33 (57) | 22 (52) | 11 (69) | |
| High dose | 25 (43) | 20 (48) | 5 (31) | |
| Tracheostomy | 19 (33) | 12 (29) | 7 (44) | 0.351 |
| CRRT | 8 (14) | 5 (12) | 3 (19) | 0.672 |
| ECMO | 10 (17) | 7 (17) | 3 (19) | 1.0 |
| Vasopressor | 28 (48) | 18 (43) | 10 (63) | 0.243 |
| Antibiotics | 57 (98) | 42 (100) | 15 (94) | 0.276 |
Data are presented as number (percentage) or as median (interquartile range).
ALI, acute lung injury; CRRT, continuous renal replacement therapy; ECMO, extracorporeal membrane oxygenation; FiO2, fraction of inspired oxygen; LIS, lung injury score; OI, oxygenation index; PaO2, partial pressure of oxygen in the arterial blood; PEEP, positive end-expiratory pressure; SOFA, sequential organ failure assessment.