Fig. 3.

Degradation of NETs improves the outcome of LPS endotoxemia. a Survival of mice injected with LPS (35 mg/kg) and treated with saline (Ctr) or rhDNase (rh, 10 mg/kg, s.c.). b The concentration of NETs in the serum of mice 18 h after LPS injection and treated or not with rhDNase. c Representative histology of the lung from infant and adult mice 18 h after injection of LPS and with or without treatment of rhDNase, ×10 magnification. Bars = 50 μm. Data are mean ± SEM, n = 4–6, representative of two experiments, *p < 0.05, **p < 0.01, and ***p < 0.001 (a Mantel-Cox log-rank test; b one-way ANOVA, Bonferroni’s)