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. 2018 Jan 23;24(3):143–157. doi: 10.1093/molehr/gay003

Figure 2.

Figure 2

OVS arise from the apocrine pathway. (A) TEM of murine oviductal epithelium. Red arrows show blebs, containing OVS, in the lumen (LUM) among sections of cilia from the ciliated cells (CEC) and microvilli (MV) of the secretory cells (SEC). Blebs are typically found when EVs arise via the apocrine pathway (bar = 0.2 μm). (B) TEM tomographic series reveals OVS arising from the apocrine pathway. Small black arrows show different planes (B (A–F)) of an OVS-containing bleb, released from the epithelium. Large black arrows show different planes of the 3D structure of an EV, not seen for microvilli (green arrow) or cilia (yellow arrow). B (G) An enlarged 3D surface rendering overlaid on the last slide (B (F)) of the tomogram with the bleb (containing blue EVs) seen in red, an isolated exosome (blue) is at the top right, microvilli (green) and a cilium (yellow) are seen (bar = 0.5 μm).