Table 2.
Laboratory data for the 20 subjects with PCOS before and after exenatide therapy.
| Baseline n = 20 | After therapy n = 20 | p-value | |
|---|---|---|---|
| ALT (IU/L) | 32.5 ± 2.9 | 32.2 ± 3.3 | 0.84 |
| CRP (mmol/L) | 8.5 ± 1.4 | 5.6 ± 0.9 | 0.001 |
| TC (mmol/L) | 4.4 ± 0.2 | 4.5 ± 0.2 | 0.30 |
| HDL-C (mmol/L) | 1.08 ± 0.10 | 0.98 ± 0.07 | 0.22 |
| LDL-C (mmol/L) | 3.03 ± 0.14 | 2.98 ± 0.17 | 0.67 |
| Triglycerides (mmol/L) | 1.34 ± 0.14 | 1.17 ± 0.11 | 0.037 |
| Fasting glucose (mmol/L) | 5.0 ± 0.1 | 4.8 ± 0.1 | 0.24 |
| Insulin (uIU/mL) | 18.4 ± 2.7 | 18.8 ± 2.8 | 0.90 |
| HOMA-IR | 4.13 ± 0.64 | 4.07 ± 0.67 | 0.94 |
| FAI (%) | 15.8 ± 1.9 | 14.2 ± 1.9 | 0.36 |
| SHBG (nmol/L) | 23.4 ± 1.7 | 25.1 ± 1.9 | 0.36 |
| VCAM-1 (ng/ml) | 2284.3 ± 75.4 | 2329.8 ± 77.0 | 0.42 |
| ICAM-1 (ng/ml) | 247.2 ± 12.9 | 231.3 ± 11.5 | 0.02 |
| E-selectin (ng/ml) | 38.5 ± 3.3 | 33.6 ± 2.6 | 0.03 |
| P-selectin (ng/ml) | 101.1 ± 8.2 | 87.4 ± 6.6 | 0.01 |
| LT1 (s) | 3506 ± 489 | 2469 ± 307 | 0.02 |
| LT2 (s) | 2987 ± 494 | 1926 ± 321 | 0.02 |
ALT, alanine aminotransferase; CRP, high sensitivity-C-reactive protein; TC, total cholesterol; LDL, low density lipoproteins; HDL, high density lipoproteins; HOMA-IR, homeostatic model assessment of Insulin resistance; FAI, free androgen index; SHBG, sex hormone binding globulin; VCAM, vascular cell adhesion molecule 1; ICAM, intercellular adhesion molecule 1; LT, lysis time. Data are presented as mean ± SD.