Table 2.

Summary of meta-analyses of perioperative complications in patients with Crohn’s disease on biologic therapy

Literature	Significant increase in anastomotic complications?	Significant increase in total infectious complications?
Narula et al. (2013) [75]	Not separately examined	Yes, RR = 1.93 (95% CI: 1.28–2.89)
El-Hussuna et al. (2013) [76]	Yes (low bias studies), RR = 1.63 (95% CI: 1.03–2.60) No (medium bias studies), RR = 0.17 (95% CI: 0.05–0.60)	No, RR = 1.15 (95% CI: 0.86–1.53)
Kopylov et al. (2012) [77]	No, OR =1.18 (95% CI: 0.61–2.30)	No, OR = 1.62 (95% CI: 0.92–2.86)
Billioud et al. (2013) [78]	Not separately examined	Yes, OR = 1.45 (95% CI: 1.03–2.05)
Waterland et al. (2016) [79]	No, OR = 1.19 (95% CI: 0.82–1.71)	Yes, OR = 1.52 (95% CI: 1.14–2.03)
Yang et al. (2014) [80]	Not separately examined	Yes, OR = 1.47 (95% CI: 1.08–1.99)

OR, odds ratio; RR, relative risk; CI, confidence interval.