Table 2.
Patient and treatment characteristics in three groups before and after propensity score matching
| Before matching |
After matching |
|||||||
|---|---|---|---|---|---|---|---|---|
| nCRT group | nCT group | Control group |
nCRT group | nCT group | Control group |
|||
| Variable | (n = 54) | (n = 48) | (n = 59) | P-value | (n = 48) | (n = 48) | (n = 48) | P-value |
| Age (years) | 50.5 (29–70) | 59 (22–77) | 59 (29–81) | 0.003 | 51.5 (30–70) | 59 (22–77) | 57 (29–81) | 0.064 |
| BMI (kg/m2) | 22.8 (17.5–27.6) | 22.9 (16.4–32.8) | 22.0 (14.2–32.8) | 0.641 | 22.7 (17.5–27.6) | 22.9 (16.4–32.8) | 22.3 (14.2–32.8) | 0.616 |
| Gender | 0.878 | 0.567 | ||||||
| Female | 19 (35.2) | 15 (31.3) | 21 (35.6) | 18 (37.5) | 15 (31.3) | 20 (41.7) | ||
| Male | 35 (64.8) | 33 (68.7) | 38 (64.4) | 30 (62.5) | 33 (68.7) | 28 (58.3) | ||
| Tumor stage | 0.002 | 0.264 | ||||||
| II | 4 (7.4) | 5 (10.4) | 18 (30.5) | 4 (8.3) | 5 (10.4) | 9 (18.8) | ||
| III | 50 (92.6) | 43 (89.6) | 41 (69.5) | 44 (91.7) | 43 (89.6) | 39 (81.2) | ||
| Tumor locationa | 0.436 | 0.419 | ||||||
| ≤7 cm | 27 (50.0) | 18 (37.5) | 25 (42.4) | 24 (50.0) | 18 (37.5) | 23 (47.9) | ||
| >7 cm | 27 (50.0) | 30 (62.5) | 34 (57.6) | 24 (50.0) | 30 (62.5) | 25 (52.1) | ||
| Chemotherapy | NA | NA | ||||||
| 5-FU | 23 (42.6) | 0 | NA | 22 (45.8) | 0 | NA | ||
| FOLFOX | 31 (57.4) | 48 (100) | NA | 26 (54.2) | 48 (100) | NA | ||
| Diverting stoma | < 0.001 | < 0.001 | ||||||
| Yes | 52 (96.3) | 20 (41.7) | 16 (27.1) | 46 (95.8) | 20 (41.7) | 16 (33.3) | ||
| No | 2 (3.7) | 28 (58.3) | 43 (72.9) | 2 (4.2) | 28 (58.3) | 32 (66.7) | ||
| Type of anastomosis | 0.819 | 0.929 | ||||||
| Sigmoid colon-rectum | 50 (92.6) | 43 (89.6) | 55 (93.2) | 45 (93.8) | 43 (89.6) | 44 (91.7) | ||
| Descending colon-rectum | 4 (7.4) | 5 (10.4) | 4 (6.8) | 3 (6.2) | 5 (10.4) | 4 (8.3) | ||
| Proximal margin (cm)b | 7.8 (3.0–15.5) | 6.4 (2.3–17.3) | 6.5 (2.3–18.0) | 0.030 | 7.0 (3.0–15.5) | 6.4 (2.3–17.3) | 6.5 (2.3–18.0) | 0.219 |
| Distal margin (cm)b | 2.0 (0.5–5.0) | 2.0 (0.5–6.5) | 2.0 (0.5–4.5) | 0.868 | 2.0 (0.5–5.0) | 2.0 (0.5–6.5) | 2.0 (0.5–4.5) | 0.855 |
| Anastomotic leakage | 0.071 | 0.017 | ||||||
| Clinical | 5 (9.3) | 2 (4.1) | 6 (10.2) | 5 (10.4) | 2 (4.1) | 4 (8.3) | ||
| Radiologic | 8 (14.8) | 3 (6.3) | 1 (1.7) | 8 (16.7) | 3 (6.3) | 0 | ||
| None | 41 (75.9) | 43 (89.6) | 52 (88.1) | 35 (72.9) | 43 (89.6) | 44 (91.7) | ||
Data are expressed as median (range) or number of patients (%).
nCRT, neoadjuvant chemoradiotherapy; nCT, neoadjuvant chemotherapy; BMI, body mass index; 5-FU, 5-fluorouracil; FOLFOX, fluorouracil, leucovorin and oxaliplatin; NA, not applicable.
aDistance from anal verge.
bLength measured in formalin-fixed specimens.