Table 4.
Univariate relationships between change in mPDAI scores and several categorical variables of interest
| Factor | No. | Post – pre clinical mPDAI |
Post – pre endoscopic mPDAI |
Post – pre total mPDAI |
|||
|---|---|---|---|---|---|---|---|
| Median | P-value | Median | P-value | Median | P-value | ||
| Gender | 0.76 | 0.097 | 0.21 | ||||
| Male | 10 | 0.00 [–1.00, 0.00] | –2.0 [–3.0, –2.0] | –2.0 [–3.0, –2.0] | |||
| Female | 9 | 0.00 [–1.00, 0.00] | –1.00 [–2.0, 2.0] | –2.0 [–2.0, 2.0] | |||
| Smoking | 0.73 | 0.39 | 0.39 | ||||
| Past | 5 | 0.00 [–1.00, 0.00] | –2.0 [–2.0, –2.0] | –2.0 [–3.0, –2.0] | |||
| Never | 14 | 0.00 [–1.00, 0.00] | –2.0 [–2.0, 2.0] | –2.0 [–3.0, 1.00] | |||
| Family history of IBD | 0.75 | 0.52 | 0.53 | ||||
| No | 13 | 0.00 [–1.00, 0.00] | –2.0 [–2.0, 0.00] | –2.0 [–3.0, 0.00] | |||
| Yes | 6 | 0.00 [–1.00, 0.00] | –2.0 [–3.0, –1.00] | –2.0 [–3.0, –2.0] | |||
| Prior surgical history | 0.50 | 0.23 | 0.23 | ||||
| No | 14 | 0.00 [–1.00, 0.00] | –2.0 [–3.0, 0.00] | –2.0 [–3.0, 0.00] | |||
| Yes | 5 | 0.00 [0.00, 0.00] | –1.00 [–2.0, –1.00] | –2.0 [–2.0, –1.00] | |||
| Extra-intestinal manifestation | 0.071 | 0.47 | 0.36 | ||||
| No | 10 | –0.50 [–1.00, 0.00] | –2.0 [–2.0, –1.00] | –2.0 [–3.0, –2.0] | |||
| Yes | 9 | 0.00 [0.00, 0.00] | –2.0 [–2.0, 2.0] | –2.0 [–3.0, 2.0] | |||
| NSAIDs | 0.76 | 0.39 | 0.64 | ||||
| None | 9 | 0.00 [–1.00, 0.00] | –2.0 [–4.0, –1.00] | –2.0 [–4.0, –1.00] | |||
| Past or present | 10 | 0.00 [–1.00, 0.00] | –2.0 [–2.0, 0.00] | –2.0 [–3.0, 0.00] | |||
| Clostridium difficile of pouch | 0.73 | 0.56 | 0.57 | ||||
| Never | 14 | 0.00 [–1.00, 0.00] | –2.0 [–2.0, 0.00] | –2.0 [–3.0, 0.00] | |||
| Past | 5 | 0.00 [–1.00, 0.00] | –2.0 [–2.0, –2.0] | –2.0 [–3.0, –2.0] | |||
| Biologics prior to colectomy | 0.37 | 0.055 | 0.054 | ||||
| No | 10 | 0.00 [–1.00, 0.00] | –2.0 [–3.0, –2.0] | –2.0 [–3.0, –2.0] | |||
| Yes | 9 | 0.00 [0.00, 0.00] | 0.00 [–2.0, 2.0] | 0.00 [–2.0, 2.0] | |||
| Pre-colectomy infliximab | 0.33 | 0.12 | 0.079 | ||||
| No | 13 | 0.00 [–1.00, 0.00] | –2.0 [–2.0, –2.0] | –2.0 [–3.0, –2.0] | |||
| Yes | 6 | 0.00 [0.00, 0.00] | 1.00 [–2.0, 2.0] | 0.50 [–2.0, 2.0] | |||
| Pre-colectomy adalimunab | 0.99 | 0.020 | 0.038 | ||||
| No | 13 | 0.00 [–1.00, 0.00] | –2.0 [–3.0, –2.0] | –2.0 [–3.0, –2.0] | |||
| Yes | 6 | 0.00 [–1.00, 0.00] | 1.00 [–2.0, 4.0] | 0.50 [–2.0, 4.0] | |||
| Mesalamine (>3 months) | 0.76 | 0.25 | 0.43 | ||||
| No | 7 | 0.00 [–1.00, 0.00] | –1.00 [–2.0, 4.0] | –2.0 [–3.0, 4.0] | |||
| Yes | 12 | 0.00 [–1.00, 0.00] | –2.0 [–2.5, –1.00] | –2.0 [–3.0, –1.00] | |||
| Topical steroids (>3 months) | 0.76 | 0.39 | 0.64 | ||||
| No | 9 | 0.00 [–1.00, 0.00] | –1.00 [–2.0, 0.00] | –2.0 [–3.0, 0.00] | |||
| Yes | 10 | 0.00 [–1.00, 0.00] | –2.0 [–2.0, –2.0] | –2.0 [–3.0, –2.0] | |||
| Pre-vedolizumab biologics | 0.23 | 0.86 | 0.83 | ||||
| No | 9 | 0.00 [–1.00, 0.00] | –2.0 [–2.0, 0.00] | –2.0 [–3.0, 0.00] | |||
| Yes | 10 | 0.00 [0.00, 0.00] | –2.0 [–2.0, –1.00] | –2.0 [–3.0, –1.00] | |||
Data presented as Median [P25, P75]. P-values correspond to Kruskal–Wallis test.
mPDAI, modified pouch disease activity index; IBD, inflammatory bowel disease; NSAIDs, non-steroidal anti-inflammatory drugs.