Table 1.
Summary of circRNAs associated with autoimmune diseases.
| Disease | circRNA | Alias | circRNA classification | Position | Regulation | Fold change | Gene | Putative function | miRNA sponged | Target gene/pathway | References |
|---|---|---|---|---|---|---|---|---|---|---|---|
| RA | hsa_circRNA_104871 | – | Exonic | chr9 | Upregulated | 1.54 | SUSD1 | – | – | – | (49) |
| RA | hsa_circRNA_102902 | hsa_circ_0057980 | Exonic | chr2 | Downregulated | 0.18 | PIKFVVE | miRNA sponge | miR−181d | – | (50) |
| RA | hsa_circRNA_104881 | hsa_circ_0088088 | Exonic | chr9 | Downregulated | 0.18 | HSDL2 | miRNA sponge | miR-16-5p | – | (50) |
| RA | hsa_circRNA_000931 | hsa_circ_0001045 | Intronic | chr2 | Upregulated | 2.7 | MRPS5 | miRNA sponge | miR-30a | BAFF | (50) |
| RA | – | hsa_circ_0044235 | Exonic | chr17 | Downregulated | 0.5 | CDC27 | miRNA sponge | miR-892a | – | (51) |
| RA | ciRS-7 | hsa_circ_0001946 | Antisense | chrX | Upregulated | 4.0 | CDR1 | miRNA sponge | miR-7 miR-671 |
PI3K/AKT | (52) |
| SLE | hsa_circRNA_400011 | hsa_circ_0092374 | Intronic | chr1 | Upregulated | 4.8 | GADD45A | miRNA sponge | miR-296-3p miR-146b-3p miR-181d-3p miR-504-3p miR-328-5p |
– | (53) |
| SLE | hsa_circRNA_102584 | hsa_circ_0003146 | Exonic | chr19 | Upregulated | 7.1 | EHD2 | miRNA sponge | miR-766-3p miR-762 miR-412-3p let-7i-3p miR-431-3P |
– | (53) |
| SLE | hsa_circRNA_101471 | hsa_circ_0034398 | Exonic | chr15 | Upregulated | 6.5 | C15orf41 | miRNA sponge | miR-136-5p miR-665 miR-486-3p miR-601 miR-30b-3p |
– | (53) |
| SLE | hsa_circRNA_100226 | hsa_circ_0005567 | Exonic | chr1 | Downregulated | 0.37 | EPS15 | miRNA sponge | miR-138-5p miR-145-3p miR-24-3p miR-620 miR-875-3p |
– | (53) |
| SLE | hsa_circRNA_102165 | hsa_circ_0045272 | Exonic | chr17 | Downregulated | 0.5 | ERN1 | miRNA sponge | miR-6127 | PAX8 DTX4 | (54) |
| SLE | hsa_circ_0077179 | Exonic | chr6 | Downregulated | 0.12 | IBTK | miRNA sponge | miR-29b | AKT | (55) | |
| MS | hsa_circRNA_101539 | hsa_circ_0005402 | Exonic | chr15 | Downregulated | 0.16 | ANXA2 | miRNA sponge | miR-1248 miR-766 |
– | (56) |
| MS | hsa_circRNA_101541 | hsa_circ_0003452_2 | Exonic | chr15 | Downregulated | 0.24 | ANXA2 | – | – | – | (56) |
| MS | – | hsa_circ_0106803 | Exonic | chr17 | Upregulated | 2.8 | GSDMB | miRNA sponge | miR-1275 miR-149 |
ASIC1 | (57) |
| LN | hsa_circHLA-C | – | – | chr15 | Upregulated | 2.72 | HLA-C | miRNA sponge | miR-4739 miR-6825-5p miR-6831-5p miR-6756-5p miR-3916 |
NF-κB | (58) |
| LN | hsa_circRNA_002453 | – | – | – | Upregulated | 5.6 | RAD18 | – | – | – | (59) |
| PBC | – | hsa_circ_402458 | Exonic | chr2 | Upregulated | 1.86 | CCNYL1 | miRNA sponge | miR-522-3p miR-943 |
TGF-β | (60) |