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. 2019 Apr 2;9:209. doi: 10.3389/fonc.2019.00209

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Copyright © 2019 Schenk, Matar, Hanekamp, Hawley, Huang and Duran-Struuck.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The percent of original weight of NSG mice that was lost/gained after administration of PTLD tumor cells before death. 5/7 mice had a significant weight loss, while two stayed relatively the same. (B) Survival curve for the 7 NSG mice injected with PTLD 13271. Median survival time (MST) = 60 days. (C) Representative gross pathology from the first passage of PTLD 13271 into NSG demonstrates severe organomegaly compared to normal controls. (D) Survival curve for the 19 NSG mice injected with CML 14736. 13/19 mice (68%) developed swine CML with a MST = 190 days. Notch marks represent mice that died but did not have swine CML.